SC5D

Across TCGA patient cohorts, SC5D mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SC5D-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and Notch1. Each is linked with SC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both SC5D-to-partner and partner-to-SC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SC5D-low versus SC5D-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SC5D→partner) and Y-score (partner→SC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.225	-3.584	<.001	.002	3	2
UCEC	MEK1 →	+0.437	+3.321	.002	.009	3	2
UCEC	Notch1 →	+0.119	+2.331	.031	.019	3	2
UCEC	S6_pS240_S244 →	+0.538	+2.807	<.001	.003	3	2
UCEC	STAT3_pY705 →	-0.492	-2.502	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.598	+1.584	.010	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

JNK_pT183_Y185 by SC5D expression — UCEC

Explore this box plot interactively →