SC5D

Across TCGA cell cohorts, SC5D mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SC5D-associated genes across cancer lineages are TBX22, SNTG2, and FMR1NB. Each is linked with SC5D in more than 1 cancer types. Because this analysis shows association rather than direction, both SC5D-to-partner and partner-to-SC5D results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TBX22 grouped by SC5D-low versus SC5D-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SC5D→partner) and Y-score (partner→SC5D) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TBX22 →	+0.030	+3.632	<.001	.003	3	1
LARGE_INTESTINE	SNTG2 →	+0.154	+3.789	.001	.004	3	1
LARGE_INTESTINE	FMR1NB →	+0.238	+3.716	<.001	.008	3	1
LARGE_INTESTINE	TFDP3 →	+0.018	+3.196	.003	.007	3	1
LARGE_INTESTINE	UBE2QL1 →	+0.194	+3.722	.002	.007	3	1
LARGE_INTESTINE	NEXMIF →	+0.296	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

TBX22 by SC5D expression — LARGE_INTESTINE

Explore this box plot interactively →