SBSPON

Across TCGA pan-cancer cohorts, SBSPON mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SBSPON data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SBSPON mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SBSPON expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LUAD, CCRCC, and PDAC are the cancer types where SBSPON mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Tertile	II,III,IV	0.695	0.994	.005	21	view →
CCRCC	DFS	Median	II,III,IV	0.295	0.827	.010	5	view →
PDAC	OS	Tertile	III,IV	0.204	0.569	.049	2	view →
HNSC	DFS	Median	All	0.561	0.721	.036	1	view →
LSCC	OS	Median	All	0.923	0.850	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SBSPON–LUAD (DFS)

Open the LUAD breakdown →