Across TCGA pan-cancer cohorts, SBSN Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated SBSN data layer compared with 29 for mass-spec protein and 6 for mass-spec protein.
The strongest signal is observed in esophageal carcinoma (ESCA), where higher SBSN Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SBSN expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.
ESCA, READ, and LIHC are the cancer types where SBSN Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.