Across TCGA patient cohorts, SBSN mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBSN-associated genes across cancer lineages are Cyclin-B1, MEK1, and p62 Lck ligand. Each is linked with SBSN in more than 2 cancer types. Because this analysis shows association rather than direction, both SBSN-to-partner and partner-to-SBSN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBSN→partner) and Y-score (partner→SBSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.585	+1.700	.014	.044	3	3
UCEC	MEK1 →	+0.484	+4.000	.001	<.001	3	2
UCEC	p62 Lck ligand →	+0.458	+2.906	<.001	.001	3	2
LUAD	Bap1-c-4 →	+0.238	+2.824	.031	.036	3	1
UCEC	EGFR_pY1068 →	-0.238	-2.222	.025	.011	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.321	.006	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

Exploration

SBSN survival (RNA) · tumor vs normal (RNA) · all SBSN data types