Across TCGA cell cohorts, SBSN mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SBSN-associated genes across cancer lineages are OR4F15, SHCBP1L, and IFNL3. Each is linked with SBSN in more than 1 cancer types. Because this analysis shows association rather than direction, both SBSN-to-partner and partner-to-SBSN results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBSN→partner) and Y-score (partner→SBSN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F15 →	+0.015	+4.977	<.001	.007	3	1
LUNG_SCLC	SHCBP1L →	+0.365	+4.817	<.001	.001	3	1
LUNG_SCLC	IFNL3 →	+0.061	+4.817	<.001	.001	3	1
LUNG_SCLC	GOLGA6L6 →	+0.019	+4.044	.006	.009	3	1
SKIN	MMP26 →	+0.026	+6.022	<.001	.001	3	1
SKIN	GALP →	+0.022	+5.415	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SBSN survival (RNA) · tumor vs normal (RNA) · all SBSN data types