SBK3

Across TCGA cell cohorts, SBK3 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SBK3-associated genes across cancer lineages are ACP4, ODF1, and MMP26. Each is linked with SBK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SBK3-to-partner and partner-to-SBK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACP4 grouped by SBK3-low versus SBK3-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBK3→partner) and Y-score (partner→SBK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ACP4 →	+0.016	+3.196	<.001	.007	3	1
SKIN	ODF1 →	+0.013	+4.022	<.001	.006	3	1
SKIN	MMP26 →	+0.013	+4.022	<.001	.006	3	1
SKIN	OR6C70 →	+0.055	+3.632	<.001	.003	3	1
SKIN	FAM153CP →	+0.136	+3.693	<.001	.005	3	1
SKIN	TCP11X2 →	+0.009	+4.099	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ACP4 by SBK3 expression — SKIN

Explore this box plot interactively →