Across TCGA cell cohorts, SBK1 mutation is significantly associated with the RNA expression of many other genes, with 504 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SBK1-associated genes across cancer lineages are TSPO2, SLC10A2, and BHLHE23. Each is linked with SBK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SBK1-to-partner and partner-to-SBK1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBK1→partner) and Y-score (partner→SBK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TSPO2 →	+0.060	+3.978	<.001	.005	3	1
CNS	SLC10A2 →	+0.093	+4.285	<.001	.001	3	1
CNS	BHLHE23 →	+0.013	+4.169	<.001	.008	3	1
CNS	LIPM →	+0.076	+3.643	<.001	.007	3	1
CNS	TAS1R2 →	+0.012	+3.643	<.001	.007	3	1
CNS	KRTAP5-10 →	+0.030	+4.201	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 504 associations by consensus.

Exploration

SBK1 survival (RNA) · tumor vs normal (RNA) · all SBK1 data types