SBF1

Across TCGA pan-cancer cohorts, SBF1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated SBF1 data layer compared with 27 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SBF1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated SBF1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

BLCA, LIHC, and MESO are the cancer types where SBF1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	II,III,IV	1.000	0.698	.008	24	view →
LIHC	OS	Median	All	0.051	0.775	<.001	24	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
UCEC	DFS	Median	All	0.937	0.624	.016	8	view →
ACC	OS	Median	All	0.177	0.632	.021	7	view →
KIRC	DFS	Median	All	0.127	0.865	<.001	6	view →
ESCA	OS	Median	II,III,IV	0.329	0.707	.014	6	view →
PRAD	DFS	Median	All	0.085	0.774	.003	6	view →
HNSC	OS	Median	All	0.303	0.608	.039	6	view →
COAD	DFS	Median	III,IV	0.146	0.616	.026	6	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

SBF1–BLCA (OS)

Open the BLCA breakdown →