SBF1

Across TCGA patient cohorts, SBF1 mutation is significantly associated with the total protein of many other genes, with 53 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBF1-associated genes across cancer lineages are 4E-BP1, Notch1, and Rad50. Each is linked with SBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SBF1-to-partner and partner-to-SBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SBF1-low versus SBF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBF1→partner) and Y-score (partner→SBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.309	+2.532	<.001	<.001	3	3
UCEC	Notch1 →	+0.156	+1.584	<.001	.005	3	2
UCEC	Rad50 →	-0.272	-2.432	<.001	<.001	3	2
COAD	Shc_pY317 →	-0.141	-1.898	.020	.016	3	2
UCEC	STAT3_pY705 →	-0.340	-1.584	<.001	.005	3	2
UCEC	VHL →	-0.658	-1.584	.002	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 53 associations by consensus.

4E-BP1 by SBF1 expression — UCEC

Explore this box plot interactively →