SBF1

Across TCGA cell cohorts, SBF1 mutation is significantly associated with the RNA expression of many other genes, with 2,047 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SBF1-associated genes across cancer lineages are TRAPPC13, GCH1, and PXYLP1. Each is linked with SBF1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SBF1-to-partner and partner-to-SBF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRAPPC13 grouped by SBF1-low versus SBF1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBF1→partner) and Y-score (partner→SBF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TRAPPC13 →	+0.389	+2.130	.003	<.001	3	3
LARGE_INTESTINE	GCH1 →	+0.536	+1.721	.001	.003	3	3
LARGE_INTESTINE	PXYLP1 →	+0.813	+3.459	<.001	<.001	3	3
LARGE_INTESTINE	ALG6 →	+0.591	+2.714	<.001	<.001	3	3
LUNG_NSCLC_LUSC	OR1L3 →	+0.060	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GAGE12F →	+1.263	+4.643	.002	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,047 associations by consensus.

TRAPPC13 by SBF1 expression — LARGE_INTESTINE

Explore this box plot interactively →