SBDS

Across TCGA patient cohorts, SBDS mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SBDS-associated genes across cancer lineages are EGFR_pY1068, JNK_pT183_Y185, and Notch1. Each is linked with SBDS in more than 1 cancer types. Because this analysis shows association rather than direction, both SBDS-to-partner and partner-to-SBDS results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by SBDS-low versus SBDS-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SBDS→partner) and Y-score (partner→SBDS) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.300	-3.169	.017	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.166	-2.308	.049	.036	3	1
UCEC	Notch1 →	+0.244	+2.321	<.001	.035	3	1
UCEC	p62 Lck ligand →	+0.433	+3.009	.008	.019	3	1
UCEC	Paxillin →	+0.287	+2.321	.027	.035	3	1
UCEC	Annexin-1 →	+0.768	+3.189	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

EGFR_pY1068 by SBDS expression — UCEC

Explore this box plot interactively →