SAYSD1

Across TCGA pan-cancer cohorts, SAYSD1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAYSD1 data layer compared with 21 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAYSD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAYSD1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where SAYSD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.570	1.000	.014	28	view →
LSCC	OS	Quartile	All	0.684	1.000	.018	4	view →
PDAC	OS	Quartile	III,IV	0.986	0.557	.017	3	view →
GBM	OS	Median	All	0.877	0.689	.004	3	view →
LUAD	OS	Median	III,IV	0.707	0.230	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAYSD1–HNSC (DFS)

Open the HNSC breakdown →