SAYSD1

Across TCGA patient cohorts, SAYSD1 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAYSD1-associated genes across cancer lineages are FOXO3a, JNK2, and Notch1. Each is linked with SAYSD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAYSD1-to-partner and partner-to-SAYSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by SAYSD1-low versus SAYSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAYSD1→partner) and Y-score (partner→SAYSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	-0.107	-2.970	.036	.036	3	1
UCEC	JNK2 →	+0.236	+2.321	.017	.035	3	1
UCEC	Notch1 →	+0.164	+3.459	.020	.005	3	1
UCEC	PCNA →	+0.268	+3.169	.013	.019	3	1
UCEC	ERK2 →	+0.195	+2.321	.044	.035	2	1
UCEC	p38-MAPK_pT180_Y182 →	-0.620	-2.308	.006	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

FOXO3a by SAYSD1 expression — UCEC

Explore this box plot interactively →