SAXO1

Across TCGA patient cohorts, SAXO1 mutation is significantly associated with the RNA expression of many other genes, with 1,318 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAXO1-associated genes across cancer lineages are UBE2V2P1, H2AW, and ZNF749. Each is linked with SAXO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SAXO1-to-partner and partner-to-SAXO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2V2P1 grouped by SAXO1-low versus SAXO1-high in PRAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAXO1→partner) and Y-score (partner→SAXO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PRAD	UBE2V2P1 →	+0.152	+5.109	<.001	.008	3	2
UCEC	H2AW →	-0.757	-1.938	.001	.001	3	2
UCEC	ZNF749 →	+0.363	+2.436	.009	.001	3	2
UCEC	OR6C72P →	+0.031	+2.384	.003	.007	3	2
UCEC	RNU6-206P →	+0.149	+3.129	<.001	.004	3	2
UCEC	RNA5SP146 →	+0.290	+2.132	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,318 associations by consensus.

UBE2V2P1 by SAXO1 expression — PRAD

Explore this box plot interactively →