SATB2

Across TCGA patient cohorts, SATB2 mutation is significantly associated with the RNA expression of many other genes, with 5,284 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SATB2-associated genes across cancer lineages are GINS2, CENPU, and PBK. Each is linked with SATB2 in more than 4 cancer types. Because this analysis shows association rather than direction, both SATB2-to-partner and partner-to-SATB2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GINS2 grouped by SATB2-low versus SATB2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SATB2→partner) and Y-score (partner→SATB2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GINS2 →	+0.844	+2.113	<.001	<.001	3	5
SKCM	CENPU →	+0.637	+1.756	.003	.004	3	5
UCEC	PBK →	+0.694	+1.595	<.001	<.001	3	5
UCEC	OIP5 →	+0.710	+1.919	<.001	<.001	3	4
LUAD	MND1 →	+0.659	+2.819	.004	.001	3	4
UCEC	PIMREG →	+0.603	+1.758	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,284 associations by consensus.

GINS2 by SATB2 expression — UCEC

Explore this box plot interactively →