SAT2

Across TCGA pan-cancer cohorts, SAT2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SAT2 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SAT2 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SAT2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LUAD show a favorable association.

UCEC, CCRCC, and OV are the cancer types where SAT2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	II,III,IV	0.500	1.000	.008	32	view →
CCRCC	OS	Quartile	All	1.000	0.872	.015	16	view →
OV	DFS	Quartile	All	0.643	1.000	.045	8	view →
PDAC	OS	Quartile	III,IV	0.577	0.977	.049	2	view →
LUAD	DFS	Quartile	All	0.779	0.423	.015	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SAT2–UCEC (DFS)

Open the UCEC breakdown →