SAT1

Across TCGA pan-cancer cohorts, SAT1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SAT1’s most consistent transcriptional readouts.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where SAT1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SAT1 is over-expressed in tumor, although a few such as KICH and KIRP show the opposite, repressed pattern.

UCEC, KICH, and KIRP are the cancer types where SAT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
UCEC	All	III,IV	+1.588	<.001	6	view →
KICH	All	II,III,IV	−0.824	.001	5	view →
KIRP	All	II,III,IV	−0.810	.002	4	view →
COAD	Male	II,III,IV	+0.681	.002	4	view →
STAD	All	All	+0.668	.007	4	view →
LUAD	Male	All	−0.601	<.001	4	view →
LUSC	All	All	−0.412	.006	4	view →
ESCA	All	All	+1.252	.003	2	view →
PAAD	All	All	−1.035	.020	2	view →
READ	All	All	+0.867	.014	2	view →
BLCA	Male	IV	+1.515	.040	1	view →
CHOL	Male	All	+0.980	.044	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SAT1–UCEC

Open the UCEC breakdown →