SASS6

Across TCGA pan-cancer cohorts, SASS6 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SASS6 data layer compared with 24 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SASS6 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SASS6 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where SASS6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Median	III,IV	0.901	0.419	.008	25	view →
PDAC	DFS	Quartile	All	0.965	0.542	.020	9	view →
HNSC	DFS	Quartile	III,IV	0.324	1.000	.040	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SASS6–LSCC (OS)

Open the LSCC breakdown →