SASH3

Across TCGA pan-cancer cohorts, SASH3 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SASH3 data layer compared with 22 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher SASH3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated SASH3 expression acts as an unfavorable survival marker.

SKCM, OV, and PRAD are the cancer types where SASH3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.361	0.698	<.001	23	view →
OV	DFS	Median	II,III,IV	0.195	0.541	.015	18	view →
PRAD	DFS	Median	All	0.200	0.775	.013	6	view →
LGG	OS	Median	All	0.511	0.830	.042	3	view →
THCA	DFS	Median	All	0.652	0.944	.032	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SASH3–SKCM (DFS)

Open the SKCM breakdown →