SASH3

Across TCGA pan-cancer cohorts, SASH3 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SASH3 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SASH3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SASH3 expression acts as an unfavorable survival marker, although some lineages such as LUAD and PDAC show a favorable association.

HNSC, LUAD, and PDAC are the cancer types where SASH3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.909	0.994	.006	14	view →
LUAD	DFS	Median	All	0.795	0.464	.004	12	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	10	view →
GBM	DFS	Quartile	All	0.617	0.797	.022	6	view →
LSCC	DFS	Tertile	II,III,IV	0.482	0.849	.014	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SASH3–HNSC (DFS)

Open the HNSC breakdown →