SASH3

Across TCGA patient cohorts, SASH3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SASH3-associated genes across cancer lineages are Notch1, STAT3_pY705, and EGFR_pY1068. Each is linked with SASH3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SASH3-to-partner and partner-to-SASH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by SASH3-low versus SASH3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH3→partner) and Y-score (partner→SASH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.167	+2.335	.001	.018	3	2
UCEC	STAT3_pY705 →	-0.455	-3.321	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.213	-1.765	.023	.014	3	1
UCEC	eIF4E →	+0.180	+1.765	.022	.014	3	1
UCEC	A-Raf_pS299 →	-0.150	-2.115	<.001	.017	3	1
UCEC	FoxM1 →	+0.236	+1.765	.015	.014	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Notch1 by SASH3 expression — UCEC

Explore this box plot interactively →