SASH3

Across TCGA cell cohorts, SASH3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,818 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SASH3-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Positive regulation of mRNA metabolic process, and Post-transcriptional gene silencing. Each is linked with SASH3 in more than 9 cancer types. Because this analysis shows association rather than direction, both SASH3-to-partner and partner-to-SASH3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by SASH3-low versus SASH3-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SASH3→partner) and Y-score (partner→SASH3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.115	+0.415	<.001	<.001	3	8
BLOOD_Lymphoma	Positive regulation of mRNA metabolic process →	+0.052	+2.414	.001	.002	3	8
OVARY	Post-transcriptional gene silencing →	+0.084	+0.113	<.001	.002	3	8
PANCREAS	Positive regulation of mRNA catabolic process →	+0.040	+0.129	.006	.006	1	10
BLOOD_Lymphoma	Regulation of DNA repair →	+0.038	+2.100	<.001	<.001	3	8
BLOOD_Leukemia	DNA damage response, signal transduction by p53 class mediator →	+0.044	+1.658	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,818 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by SASH3 expression — LUNG_SCLC

Explore this box plot interactively →