SART3

Across TCGA patient cohorts, SART3 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SART3-associated genes across cancer lineages are 4E-BP1, Annexin-1, and ATM. Each is linked with SART3 in more than 3 cancer types. Because this analysis shows association rather than direction, both SART3-to-partner and partner-to-SART3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by SART3-low versus SART3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SART3→partner) and Y-score (partner→SART3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.234	+2.807	.004	.002	3	4
UCEC	Annexin-1 →	+0.620	+3.169	<.001	<.001	3	2
UCEC	ATM →	-0.349	-1.752	.010	.011	3	2
UCEC	Chk2_pT68 →	-0.145	-2.492	.009	.001	3	2
UCEC	Cyclin-B1 →	+0.543	+2.321	.001	.005	3	2
STAD	mTOR_pS2448 →	-0.197	-3.000	.021	.036	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

4E-BP1 by SART3 expression — UCEC

Explore this box plot interactively →