SART3

Across TCGA cell cohorts, SART3 mutation is significantly associated with the mutation status of many other genes, with 6,042 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SART3-associated genes across cancer lineages are PLEKHA7, OPLAH, and PXDN. Each is linked with SART3 in more than 4 cancer types. Because this analysis shows association rather than direction, both SART3-to-partner and partner-to-SART3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PLEKHA7 grouped by SART3-low versus SART3-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SART3→partner) and Y-score (partner→SART3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PLEKHA7 →	+4.297	+4.857	.009	.009	1	5
BREAST	OPLAH →	+5.297	+5.297	.004	.004	1	5
OVARY	PXDN →	+2.754	+4.095	.009	.009	1	5
LARGE_INTESTINE	UTRN →	+1.834	+3.370	<.001	<.001	1	5
SKIN	VEPH1 →	+5.392	+4.824	.004	.004	1	5
BLOOD_Leukemia	HECTD1 →	+3.478	+4.347	<.001	<.001	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,042 associations by consensus.

PLEKHA7 by SART3 expression — BREAST

Explore this box plot interactively →