SART1

Across TCGA pan-cancer cohorts, SART1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SART1 data layer compared with 27 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SART1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SART1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, CCRCC, and LSCC are the cancer types where SART1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.671	0.950	.021	16	view →
CCRCC	OS	Quartile	All	0.884	1.000	.018	5	view →
LSCC	OS	Tertile	II,III,IV	0.941	0.686	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SART1–HNSC (OS)

Open the HNSC breakdown →