SART1

Across TCGA patient cohorts, SART1 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SART1-associated genes across cancer lineages are ERK2, ASNS, and 53BP1. Each is linked with SART1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SART1-to-partner and partner-to-SART1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by SART1-low versus SART1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SART1→partner) and Y-score (partner→SART1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.185	+2.115	.008	.017	3	2
UCEC	ASNS →	+0.424	+1.700	.001	.040	3	2
UCEC	53BP1 →	+0.310	+2.321	.013	.033	3	2
UCEC	Di-Ras3 →	-0.181	-2.308	<.001	.005	3	2
UCEC	14-3-3_beta →	-0.115	-3.673	.001	.001	3	1
UCEC	A-Raf_pS299 →	-0.132	-1.502	.002	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

ERK2 by SART1 expression — UCEC

Explore this box plot interactively →