SART1

Across TCGA cell cohorts, SART1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,807 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SART1-associated GO terms across cancer lineages are Regulation of attachment of mitotic spindle microtubules to kinetochore, Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11), and Spliceosomal conformational changes to generate catalytic conformation. Each is linked with SART1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SART1-to-partner and partner-to-SART1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of attachment of mitotic spindle microtubules to kinetochore grouped by SART1-low versus SART1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SART1→partner) and Y-score (partner→SART1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Regulation of attachment of mitotic spindle microtubules to kinetochore →	+0.149	+0.708	.003	.007	3	14
OVARY	Spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) →	+0.111	+0.734	<.001	<.001	3	14
URINARY_TRACT	Spliceosomal conformational changes to generate catalytic conformation →	+0.101	+0.942	<.001	.009	3	14
UPPER_AERODIGESTIVE_TRACT	Regulation of metaphase plate congression →	+0.156	+1.171	.004	<.001	3	13
URINARY_TRACT	Protein linear polyubiquitination →	+0.144	+0.756	.004	.007	3	13
STOMACH	Spliceosomal tri-snRNP complex assembly →	+0.106	+0.542	.002	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,807 associations by consensus.

Regulation of attachment of mitotic spindle microtubules to kinetochore by SART1 expression — LUNG_NSCLC_LUSC

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