SART1

Across TCGA cell cohorts, SART1 mutation is significantly associated with the RNA expression of many other genes, with 47 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SART1-associated genes across cancer lineages are C7orf77, RSPH4A, and L3MBTL4. Each is linked with SART1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SART1-to-partner and partner-to-SART1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C7orf77 grouped by SART1-low versus SART1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SART1→partner) and Y-score (partner→SART1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	C7orf77 →	+0.072	+4.357	<.001	.006	3	1
LARGE_INTESTINE	RSPH4A →	+0.227	+3.299	.001	.004	3	1
LARGE_INTESTINE	L3MBTL4 →	+0.563	+3.647	.004	.001	3	1
LARGE_INTESTINE	PROP1 →	+0.016	+2.639	.001	.002	3	1
LARGE_INTESTINE	OR2D3 →	+0.015	+2.510	.005	.004	3	1
LARGE_INTESTINE	NAA38 →	+0.966	+3.212	.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

C7orf77 by SART1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →