SARS2

Across TCGA patient cohorts, SARS2 mutation is significantly associated with the RNA expression of many other genes, with 4,438 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SARS2-associated genes across cancer lineages are RNA5SP451, MTATP6P21, and CCDC34P1. Each is linked with SARS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both SARS2-to-partner and partner-to-SARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP451 grouped by SARS2-low versus SARS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARS2→partner) and Y-score (partner→SARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP451 →	+0.203	+2.604	.001	.005	3	3
UCEC	MTATP6P21 →	+0.261	+1.774	<.001	.009	3	3
UCEC	CCDC34P1 →	+0.102	+2.846	.003	<.001	3	3
CESC	NCOA4P1 →	+0.032	+4.705	<.001	.003	3	3
BRCA	RNU6-982P →	+0.523	+7.731	<.001	.009	3	2
UCEC	MIR6854 →	+0.142	+2.845	.002	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,438 associations by consensus.

RNA5SP451 by SARS2 expression — UCEC

Explore this box plot interactively →