SARS2

Across TCGA cell cohorts, SARS2 protein abundance is significantly associated with the go_rna of many other GO terms, with 2,525 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SARS2-associated GO terms across cancer lineages are Positive regulation of muscle tissue development, Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, and Regulation of tumor necrosis factor superfamily cytokine production. Each is linked with SARS2 in more than 3 cancer types. Because this analysis shows association rather than direction, both SARS2-to-partner and partner-to-SARS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of muscle tissue development grouped by SARS2-low versus SARS2-high in BONE.

protein abundance associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SARS2→partner) and Y-score (partner→SARS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of muscle tissue development →	-0.174	-1.322	.001	.002	3	4
BONE	Positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway →	+0.191	+1.275	.002	.004	3	4
BONE	Regulation of tumor necrosis factor superfamily cytokine production →	+0.094	+1.482	.008	.006	3	4
BONE	Regulation of glycolytic process through fructose-6-phosphate →	+0.117	+1.582	.004	.002	3	4
BONE	Negative regulation of glycolytic process through fructose-6-phosphate →	+0.117	+1.582	.004	.002	3	4
BONE	Positive regulation of striated muscle tissue development →	-0.174	-1.322	.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,525 associations by consensus.

Positive regulation of muscle tissue development by SARS2 expression — BONE

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