SARM1

Across TCGA pan-cancer cohorts, SARM1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated SARM1 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher SARM1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SARM1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

UCEC, PDAC, and CCRCC are the cancer types where SARM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.499	1.000	.014	12	view →
PDAC	DFS	Quartile	III,IV	0.902	0.440	.027	9	view →
CCRCC	DFS	Quartile	All	1.000	0.595	.001	8	view →
LUAD	DFS	Median	II,III,IV	0.778	0.313	.031	4	view →
GBM	OS	Median	All	0.913	0.795	.023	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

SARM1–UCEC (OS)

Open the UCEC breakdown →