SARM1

Across TCGA patient cohorts, SARM1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SARM1-associated genes across cancer lineages are FOXO3a, C-Raf, and eIF4E. Each is linked with SARM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SARM1-to-partner and partner-to-SARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FOXO3a grouped by SARM1-low versus SARM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARM1→partner) and Y-score (partner→SARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FOXO3a →	+0.104	+2.199	.027	.033	3	2
UCEC	C-Raf →	+0.172	+3.169	.009	.019	3	2
UCEC	eIF4E →	+0.240	+3.013	.014	.018	3	1
UCEC	ERK2 →	+0.304	+2.584	<.001	.011	3	1
UCEC	GAPDH →	+0.816	+3.321	.001	.009	3	1
UCEC	GATA3 →	+0.174	+3.020	.049	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

FOXO3a by SARM1 expression — UCEC

Explore this box plot interactively →