SARM1

Across TCGA cell cohorts, SARM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,540 significant associations in total. LUNG_SCLC shows the largest number of these associations.

The most reproducible SARM1-associated GO terms across cancer lineages are Copper ion export, Peptidyl-serine phosphorylation, and Microtubule polymerization. Each is linked with SARM1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SARM1-to-partner and partner-to-SARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Copper ion export grouped by SARM1-low versus SARM1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SARM1→partner) and Y-score (partner→SARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Copper ion export →	-0.132	-1.438	<.001	<.001	2	10
LUNG_SCLC	Peptidyl-serine phosphorylation →	+0.115	+1.283	<.001	<.001	3	9
LUNG_SCLC	Microtubule polymerization →	+0.107	+1.373	<.001	.002	3	9
UPPER_AERODIGESTIVE_TRACT	Negative regulation of calcium ion export across plasma membrane →	+0.067	+0.854	.001	.001	3	8
OVARY	Regulation of intracellular steroid hormone receptor signaling pathway →	+0.069	+1.247	.002	.004	3	8
LUNG_SCLC	DNA-templated transcription initiation →	+0.059	+1.126	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,540 associations by consensus.

Copper ion export by SARM1 expression — SOFT_TISSUE

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