SARM1

Across TCGA cell cohorts, SARM1 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SARM1-associated genes across cancer lineages are OR1L3, OR1E3, and SPINK9. Each is linked with SARM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SARM1-to-partner and partner-to-SARM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1L3 grouped by SARM1-low versus SARM1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARM1→partner) and Y-score (partner→SARM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR1L3 →	+0.019	+5.415	<.001	.004	3	2
SKIN	OR1E3 →	+0.036	+6.022	<.001	.001	3	1
SKIN	SPINK9 →	+0.058	+5.415	<.001	.004	3	1
LARGE_INTESTINE	BPIFB6 →	+0.014	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR1L6 →	+0.015	+3.700	<.001	.009	3	1
LARGE_INTESTINE	OR10W1 →	+0.014	+3.562	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

OR1L3 by SARM1 expression — SKIN

Explore this box plot interactively →