SARAF

Across TCGA patient cohorts, SARAF protein abundance is significantly associated with the RNA expression of many other genes, with 5,804 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SARAF-associated genes across cancer lineages are GSR, PPP2CB, and LEPROTL1. Each is linked with SARAF in more than 6 cancer types. Because this analysis shows association rather than direction, both SARAF-to-partner and partner-to-SARAF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SARAF versus GSR in OV, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARAF→partner) and Y-score (partner→SARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	GSR →	+0.707	+0.351	<.001	<.001	3	7
BRCA	PPP2CB →	+0.619	+0.672	<.001	<.001	3	6
OV	LEPROTL1 →	+0.735	+0.700	<.001	<.001	3	5
OV	DCTN6 →	+0.659	+0.417	<.001	<.001	3	5
COAD	BIN3 →	+0.438	+0.460	.001	<.001	3	4
BRCA	SH2D4A →	+0.902	+0.532	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,804 associations by consensus.

SARAF vs GSR — OV

Explore this scatter interactively →