SARAF

Across TCGA cell cohorts, SARAF protein abundance is significantly associated with the RNA expression of many other genes, with 4,629 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SARAF-associated genes across cancer lineages are MED4, NRF1, and ACTN4. Each is linked with SARAF in more than 7 cancer types. Because this analysis shows association rather than direction, both SARAF-to-partner and partner-to-SARAF results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SARAF versus MED4 in URINARY_TRACT, with a Pearson correlation of 0.79.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SARAF→partner) and Y-score (partner→SARAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MED4 →	+0.973	+1.760	<.001	.004	3	8
BLOOD_Leukemia	NRF1 →	+0.740	+0.985	<.001	<.001	3	6
BLOOD_Lymphoma	ACTN4 →	-1.440	-1.011	.001	.001	3	6
BLOOD_Lymphoma	RNASEH2B →	+1.235	+1.045	<.001	<.001	3	6
LUNG_SCLC	KBTBD6 →	+0.754	+0.754	.002	<.001	3	6
LUNG_SCLC	HMGB2 →	+1.026	+0.898	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,629 associations by consensus.

SARAF vs MED4 — URINARY_TRACT

Explore this scatter interactively →