SAR1B

Across TCGA pan-cancer cohorts, SAR1B mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated SAR1B data layer compared with 25 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAR1B mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SAR1B expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, COAD, and PDAC are the cancer types where SAR1B mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.925	0.662	<.001	51	view →
COAD	DFS	Quartile	All	0.894	1.000	.049	6	view →
PDAC	OS	Median	IV	0.491	0.836	.024	6	view →
LSCC	OS	Quartile	All	0.693	0.937	.027	5	view →
CCRCC	DFS	Tertile	II,III,IV	0.915	0.399	.040	5	view →
GBM	OS	Median	All	0.457	0.590	.036	4	view →
LUAD	DFS	Median	III,IV	0.315	0.948	.008	3	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

SAR1B–HNSC (DFS)

Open the HNSC breakdown →