SAR1B

Across TCGA patient cohorts, SAR1B mutation is significantly associated with the RNA expression of many other genes, with 428 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAR1B-associated genes across cancer lineages are CCL5, MIR6859-2, and NOL12. Each is linked with SAR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SAR1B-to-partner and partner-to-SAR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCL5 grouped by SAR1B-low versus SAR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAR1B→partner) and Y-score (partner→SAR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CCL5 →	+1.075	+2.928	.005	.001	3	1
UCEC	MIR6859-2 →	+0.263	+2.231	.008	.004	3	1
UCEC	NOL12 →	+0.383	+3.491	.001	.002	3	1
UCEC	ZFP91P1 →	+0.196	+3.024	<.001	<.001	3	1
UCEC	PANO1 →	+0.460	+3.522	.001	.002	3	1
UCEC	AATF →	+0.419	+2.641	.008	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 428 associations by consensus.

CCL5 by SAR1B expression — UCEC

Explore this box plot interactively →