SAR1B

Across TCGA patient cohorts, SAR1B mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SAR1B-associated genes across cancer lineages are INPP4B, JNK2, and Ku80. Each is linked with SAR1B in more than 1 cancer types. Because this analysis shows association rather than direction, both SAR1B-to-partner and partner-to-SAR1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by SAR1B-low versus SAR1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAR1B→partner) and Y-score (partner→SAR1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.306	-2.999	.042	.035	3	1
UCEC	JNK2 →	+0.254	+2.817	.006	.036	3	1
UCEC	Ku80 →	+0.255	+1.887	.020	.031	3	1
UCEC	PDK1_pS241 →	+0.175	+1.887	.027	.031	3	1
UCEC	EGFR_pY1068 →	-0.286	-2.584	.014	.011	2	1
UCEC	Shc_pY317 →	-0.207	-3.169	.003	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

INPP4B by SAR1B expression — UCEC

Explore this box plot interactively →