SAP30L

Across TCGA pan-cancer cohorts, SAP30L mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAP30L data layer compared with 24 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAP30L mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SAP30L expression acts as an unfavorable survival marker, although some lineages such as CCRCC and LSCC show a favorable association.

HNSC, UCEC, and CCRCC are the cancer types where SAP30L mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.781	0.935	.001	37	view →
UCEC	OS	Quartile	II,III,IV	0.337	1.000	.005	12	view →
CCRCC	OS	Tertile	All	0.939	0.778	.011	7	view →
LSCC	OS	Median	II,III,IV	1.000	0.882	.021	5	view →
PDAC	OS	Median	III,IV	1.000	0.599	.022	3	view →
LUAD	OS	Tertile	II,III,IV	0.893	0.320	.006	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAP30L–HNSC (OS)

Open the HNSC breakdown →