SAP30L

Across TCGA pan-cancer cohorts, SAP30L mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of SAP30L’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SAP30L mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types SAP30L is over-expressed in tumor, although a few such as CCRCC and LSCC show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where SAP30L tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAP30L mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Female	III,IV	−0.435	<.001	12	view →
LSCC	All	All	−0.119	<.001	4	view →
LUAD	Male	III,IV	−0.254	.012	2	view →
COAD	Male	III,IV	+0.261	.012	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

SAP30L–CCRCC

Open the CCRCC breakdown →