SAP30

Across TCGA pan-cancer cohorts, SAP30 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SAP30 data layer compared with 1 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SAP30 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated SAP30 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LUSC show a favorable association.

UVM, MESO, and KICH are the cancer types where SAP30 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.430	0.832	<.001	132	view →
MESO	OS	Median	All	0.410	0.662	<.001	132	view →
KICH	OS	Median	III,IV	0.524	1.000	<.001	93	view →
KIRP	DFS	Tertile	II,III,IV	0.452	0.874	<.001	66	view →
LIHC	OS	Tertile	All	0.362	0.605	<.001	62	view →
ACC	DFS	Median	All	0.244	0.685	<.001	52	view →
LGG	OS	Median	All	0.335	0.523	<.001	48	view →
SKCM	OS	Quartile	III,IV	0.483	0.190	.001	31	view →
THCA	OS	Tertile	II,III,IV	0.525	1.000	.006	21	view →
LUSC	OS	Median	All	0.718	0.628	.011	13	view →
UCS	DFS	Median	All	0.379	0.640	.008	12	view →
HNSC	OS	Median	All	0.293	0.498	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SAP30–UVM (OS)

Open the UVM breakdown →