SAP18

Across TCGA pan-cancer cohorts, SAP18 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SAP18 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SAP18 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SAP18 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where SAP18 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.783	0.912	.002	34	view →
LSCC	OS	Quartile	II,III,IV	0.941	0.590	.018	13	view →
PDAC	OS	Tertile	All	0.349	0.578	.020	8	view →
LUAD	OS	Median	II,III,IV	0.893	0.457	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SAP18–HNSC (OS)

Open the HNSC breakdown →