SAP18

Across TCGA cell cohorts, SAP18 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,048 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SAP18-associated GO terms across cancer lineages are Sister chromatid biorientation, Positive regulation of mitotic sister chromatid separation, and Positive regulation of mitotic metaphase/anaphase transition. Each is linked with SAP18 in more than 9 cancer types. Because this analysis shows association rather than direction, both SAP18-to-partner and partner-to-SAP18 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Sister chromatid biorientation grouped by SAP18-low versus SAP18-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SAP18→partner) and Y-score (partner→SAP18) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Sister chromatid biorientation →	+0.119	+0.573	<.001	<.001	3	10
LIVER	Positive regulation of mitotic sister chromatid separation →	+0.123	+0.590	<.001	.001	3	9
LIVER	Positive regulation of mitotic metaphase/anaphase transition →	+0.128	+0.562	<.001	.004	3	9
LIVER	Positive regulation of mitotic sister chromatid segregation →	+0.155	+0.443	<.001	.005	3	9
LIVER	Spindle assembly involved in female meiosis →	+0.207	+0.495	<.001	.001	3	8
LIVER	Positive regulation of metaphase/anaphase transition of cell cycle →	+0.142	+0.448	<.001	.008	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,048 associations by consensus.

Sister chromatid biorientation by SAP18 expression — BONE

Explore this box plot interactively →