SAMSN1

Across TCGA pan-cancer cohorts, SAMSN1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SAMSN1 data layer compared with 19 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher SAMSN1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated SAMSN1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

PDAC, GBM, and LSCC are the cancer types where SAMSN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Median	III,IV	0.343	0.833	.002	14	view →
GBM	OS	Quartile	All	0.285	0.617	.004	5	view →
LSCC	DFS	Quartile	II,III,IV	0.511	0.882	.016	4	view →
UCEC	OS	Quartile	III,IV	1.000	0.288	.040	4	view →
HNSC	DFS	Median	II,III,IV	0.906	0.986	.041	2	view →
CCRCC	OS	Median	All	0.783	1.000	.030	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SAMSN1–PDAC (OS)

Open the PDAC breakdown →