SAMHD1

Across TCGA pan-cancer cohorts, SAMHD1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated SAMHD1 data layer compared with 24 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher SAMHD1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SAMHD1 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, PRAD, and STAD are the cancer types where SAMHD1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.292	0.633	.023	9	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
STAD	OS	Median	III,IV	0.217	0.648	.004	6	view →
UCEC	DFS	Median	All	0.924	0.620	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

SAMHD1–LUSC (OS)

Open the LUSC breakdown →