SAMHD1

Across TCGA pan-cancer cohorts, SAMHD1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of SAMHD1’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where SAMHD1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types SAMHD1 is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

CCRCC, LSCC, and LUAD are the cancer types where SAMHD1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SAMHD1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	+0.999	<.001	11	view →
LSCC	Male	III,IV	−0.568	<.001	8	view →
LUAD	Male	II,III,IV	−0.423	<.001	8	view →
COAD	All	II,III,IV	−0.132	.005	5	view →
PDAC	All	IV	−1.070	.001	2	view →
HNSC	All	III,IV	−0.228	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

SAMHD1–CCRCC

Open the CCRCC breakdown →