SAMHD1

Across TCGA patient cohorts, SAMHD1 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,577 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SAMHD1-associated proteins across cancer lineages are PSMB10, OAS2, and PARP14. Each is linked with SAMHD1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SAMHD1-to-partner and partner-to-SAMHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAMHD1 versus PSMB10 in HNSC, with a Pearson correlation of 0.59.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMHD1→partner) and Y-score (partner→SAMHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PSMB10 →	+0.549	+1.044	<.001	<.001	3	10
UCEC	OAS2 →	+0.851	+0.979	<.001	<.001	3	10
COAD	PARP14 →	+0.398	+0.608	<.001	<.001	3	10
HNSC	GBP1 →	+0.826	+0.843	<.001	<.001	3	10
HNSC	GBP4 →	+0.818	+1.153	<.001	<.001	3	10
GBM	HCLS1 →	+0.773	+0.602	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,577 associations by consensus.

SAMHD1 vs PSMB10 — HNSC

Explore this scatter interactively →