SAMHD1

Across TCGA patient cohorts, SAMHD1 protein abundance is significantly associated with the RNA expression of many other genes, with 17,402 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SAMHD1-associated genes across cancer lineages are SLA2, MS4A6A, and SELPLG. Each is linked with SAMHD1 in more than 9 cancer types. Because this analysis shows association rather than direction, both SAMHD1-to-partner and partner-to-SAMHD1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SAMHD1 versus SLA2 in BRCA, with a Pearson correlation of 0.74.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SAMHD1→partner) and Y-score (partner→SAMHD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	SLA2 →	+1.100	+0.502	<.001	<.001	3	10
GBM	MS4A6A →	+1.267	+0.449	<.001	<.001	3	10
GBM	SELPLG →	+1.035	+0.445	<.001	<.001	3	10
HNSC	BIN2 →	+1.007	+0.647	<.001	<.001	3	10
BRCA	CD2 →	+1.556	+0.478	<.001	<.001	3	10
BRCA	CCR2 →	+1.351	+0.460	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 17,402 associations by consensus.

SAMHD1 vs SLA2 — BRCA

Explore this scatter interactively →